Prandoni P, Lensing AWA, Carta M, Cogo A, Villalta S, Ruol A.Long-term anticoagulation is indicated in patients with a sustained high risk of arterial or venous thromboembolism.If the episode of VTE occurs late in pregnancy, anticoagulation should be continued for a total of 3 months after the episode.The most common indication for venous interruption in patients with DVT or PE is anticoagulant-induced bleeding or anticipation of hemorrhagic complications in a patient with a predisposing lesion, such as a bleeding peptic ulcer, gastrointestinal malignancy, recent intracranial operation, or an underlying hemorrhagic state (eg, liver failure or thrombocytopenia).Subcutaneous Unfractionated Heparin vs Low-Molecular-Weight Heparin for Acute Thromboembolic Disease Issues of Efficacy and Cost.The former manifestations of thrombophilia are much more common than the latter, which is sometimes seen in malignant disease.Lytic therapy in the treatment of axillary and subclavian vein thrombosis.
These patients often have fleeting attacks of sharp chest pain that last for seconds or a feeling that they cannot take a deep breath.Adjusted-dose heparin is more effective than fixed low-dose heparin in patients undergoing elective hip surgery 63 but is less effective in preventing proximal vein thrombosis than LMWH following elective hip surgery. 71 Adjusted-dose heparin is inconvenient because it requires careful laboratory monitoring.Thromboendarterectomy for chronic, major-vessel thromboembolic pulmonary hypertension: immediate and long-term results in 42 patients.Lupus anticoagulant: an analysis of the clinical and laboratory features of 219 cases.These patients may have had a previous episode of DVT and some have evidence of postthrombotic syndrome, but some have never had objectively documented episodes of venous thrombosis.Deep vein thrombosis, or DVT, occurs when a blood clot forms in one of the deep veins of the body.Other manifestations of postthrombotic syndrome are pain in the calf relieved by rest and elevation of the leg, pigmentation and induration around the ankle and the lower third of the leg, and, less commonly, ulceration and venous claudication, a bursting calf pain that occurs during exercise.Seventy-eight patients experienced one or more episodes of objectively confirmed recurrent venous thromboembolic events.
The thrombogenic effect of anticancer drug therapy in women with stage II breast cancer.Thrombotic complications during L-asparaginase treatment for acute lymphocytic leukemia.Outpatient Treatment of Deep Vein Thrombosis with Low Molecular Weight Heparin (LMWH) Clinical Practice Guideline August 2013.A reappraisal of the application of the Trendelenburg operation for massive fatal embolism.However, it is more expensive than heparin, it is associated with a higher risk of bleeding, 55 183 and it is not indicated in most patients with PE because they do well clinically with anticoagulant therapy.Lifelong anticoagulant treatment should be considered for thrombophilic patients with a documented episode of thrombosis, with or without a laboratory abnormality, while thrombophilic patients without documented evidence of thrombosis should receive prophylaxis when exposed to high-risk situations (eg, surgery, prolonged immobilization, pregnancy).
The incidence of venous thrombosis and its sequelae in certain districts in Sweden.Thus, the low absolute incidence of thrombosis in patients with temporary risk factors suggests that a short course of treatment might be appropriate for the subgroup of patients with reversible risk factors, whereas long-term anticoagulant therapy should be considered for patients without a reversible predisposing factor.Right atrial thrombus and superior vena cava syndrome in a child.
Drug details for Unfractionated heparin for deep vein thrombosis.
Pleuritic-type chest pain may accompany pericarditis or immune pleuritis.Greinacher A, Liebenhoff U, Kiefel V, Presek P, Mueller-Eckhardt C.Heparin and the In-Hospital Management of Deep Venous Thrombosis: Cost Considerations.Others have reported a lower frequency of impedance plethysmography (IPG) conversion during serial testing.In a study by Iturbe-Alessio et al, 236 10 of 35 term pregnancies in which warfarin was administered between 6 and 12 weeks were associated with warfarin embryopathy.
The use of LMW heparin in treating thromboembolism during pregnancy and prevention of osteoporosis.Complete occlusion of the filter occurred in 30% to 45% of patients due to thrombosis around the device or trapping of an embolus. 190 191 The reported rate of recurrent PE was 12%. 192 Less common complications included perforation of adjacent organs (eg, duodenum or ureter) and breakage.
Requests for reprints should be sent to the Office of Science and Medicine, American Heart Association, 7272 Greenville Ave, Dallas, TX 75231-4596.In patients who develop warfarin-induced skin necrosis, warfarin should be discontinued, vitamin K 1 should be given to increase levels of protein C, and full doses of heparin should be administered to achieve a rapid anticoagulant effect.
Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia.Comparison of the non-specific binding of unfractionated heparin and low molecular weight heparin to plasma proteins.All other combinations of clinical and lung scan probabilities require further investigation before a diagnosis of PE can be ruled in or out.Hunter JA, DeLaria GA, Goldin MD, Serry C, Monson DO, DaValle MJ, Najafi H.
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