Inactive ingredients: croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate.Drugs that Inhibit Cytochrome P450 3A4 Enzymes and Drug Transport Systems.
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For the primary efficacy analysis, all confirmed events were considered from randomization up to the end of intended treatment duration (6 or 12 months) irrespective of the actual treatment duration.In another study, single doses of warfarin (15 mg) and Xarelto (5 mg) resulted in an additive effect on factor Xa inhibition and PT.
Xarelto is indicated for the treatment of pulmonary embolism (PE).
The inactive ingredients of Xarelto are: croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate.There is insufficient experience to determine how Xarelto and warfarin compare when warfarin therapy is well-controlled.Bleeding events occurring any time following the first dose of double-blind study medication (which may have been prior to administration of active drug) until two days after the last dose of double-blind study medication.This dose corresponds to about 14 times the human exposure of unbound drug.
Bleeding event occurred after randomization and up to 2 days after the last dose of study drug.If traumatic puncture occurs, delay the administration of Xarelto for 24 hours.For patients who are unable to swallow whole tablets, 10 mg, 15 mg or 20 mg Xarelto tablets may be crushed and mixed with applesauce immediately prior to use and administered orally.Patients who required thrombectomy, insertion of a caval filter, or use of a fibrinolytic agent and patients with creatinine clearance.Do not give Xarelto to other people, even if they have the same condition.Reduction in Risk of Stroke in Nonvalvular Atrial Fibrillation ( 2.4 ).
The mean duration of treatment was 190 days for both Xarelto and placebo treatment groups.Females of reproductive potential requiring anticoagulation should discuss pregnancy planning with their physician.
Instruct patients to inform their healthcare professional that they are taking Xarelto before any invasive procedure (including dental procedures) is scheduled.Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
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