Warfarin inhibits the synthesis of clotting factors II, VII, IX, and X, as well as the naturally occurring endogenous anticoagulant proteins C and S ( 2 ).The goal of anticoagulant therapy with warfarin is to administer the lowest effective dose of the drug to maintain the target international normalized ratio (INR.
Warfarin: learn about side effects, dosage, special precautions, and more on MedlinePlus.
Vitamin K has long been known to regulate control of blood clotting.Patients who are given a loading dose of warfarin often reach a supratherapeutic INR level that can place a patient at risk for bleeding and prolonged hospital stay.Optimization of inpatient warfarin therapy: impact of daily consultation by a pharmacist-managed anticoagulation service.
Learn about Coumadin (Warfarin Sodium) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.There is no standard dosage for Coumadin that will work for everyone.This site does not dispense medical advice or advice of any kind.
Hirsh J, Dalen JE, Anderson DR, Poller L, Bussey H, Ansell J, Deykin D, Brandt JT.Not all factors responsible for warfarin dose variability are known, and the initial dose is influenced by:.It is not necessarily related to body weight, and many factors affect the dose.Taking too little increases your risk for blood clots and strokes, and taking too much increases your risk for dangerous internal bleeding.Home of Coumadin-Dosing.com, a site which specializes in Coumadin Dosing Software for both Windows XP, Vista, Palm and Windows Mobile.Frequent adjustments are often necessary, as a dosage that works well today may not be appropriate next week.
Site users seeking medical advice about their specific situation should consult with their own physician.PMCID: PMC1305837 A review of warfarin dosing and monitoring Mariamma Kuruvilla, PharmD and Cheryle Gurk-Turner, RPH 1 From the Department of Pharmacy Services, Baylor University Medical Center, Dallas, Texas.The information gathered was entered into Microsoft Access, and 50 patients were randomly selected to be included in the evaluation.
Keep in mind that an amount that works well today may not be appropriate next week.The recalled product is one lot of 1,000-count bottles of Coumadin Crystalline 5-mg tablets, with the lot number in the United States of 9H49374A and an expiration.Lastly, since warfarin has a narrow therapeutic window and has been associated with many drug-drug and drug-food interactions, patient counseling is crucial.
Warfarin, a vitamin K antagonist, is an oral anticoagulant indicated for the prevention and treatment of venous thrombosis and its extension and the prevention and treatment of the thromboembolic complications associated with atrial fibrillation.
Since life-threatening problems can occur if you take too little or too much Coumadin, dosing must be individualized for each person.This complication has been attributed to excessive depression of factor VII and protein C ( 2, 5 ).
Blood Pressure Cholesterol Congestive Heart Failure Diabetes Erectile Dysfunction Heart.The anticoagulant and antithrombotic activity of warfarin depends on the clearance of functional clotting factors from the systemic circulation once the drug is administered ( 2, 3 ).
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